Version 5.4
Homo sapiens Protein: ASF1B
Summary
InnateDB Protein IDBP-32977.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASF1B
Protein Name ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263382
InnateDB Gene IDBG-32975 (ASF1B)
Protein Structure
UniProt Annotation
Function Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. {ECO:0000269PubMed:11897662, ECO:0000269PubMed:12842904, ECO:0000269PubMed:14718166, ECO:0000269PubMed:15664198, ECO:0000269PubMed:16151251}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12842904}.
Disease Associations
Tissue Specificity Highly expressed in testis and at lower levels in colon, small intestine and thymus. {ECO:0000269PubMed:12842904}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
Experimentally validated
Total 58 [view]
Protein-Protein 55 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042393 histone binding
Biological Process
GO:0006333 chromatin assembly or disassembly
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0016568 chromatin modification
GO:0030154 cell differentiation
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR006818 Histone chaperone, ASF1-like
PFAM PF04729
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NVP2
PhosphoSite PhosphoSite-Q9NVP2
TrEMBL B4DXU6
UniProt Splice Variant
Entrez Gene 55723
UniGene
RefSeq NP_060624
HUGO HGNC:20996
OMIM 609190
CCDS CCDS12306
HPRD 16460
IMGT
EMBL AB104486 AC022098 AF279307 AK001288 AK001466 AK223080 AK302134 BC007726 BC010014 BC036521 CH471106 CR457235
GenPept AAH07726 AAH10014 AAH36521 AAK82973 BAA91602 BAA91708 BAC87709 BAD96800 BAG63508 CAG33516 EAW84401 EAW84402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca