Homo sapiens Protein: INTS12
Summary
InnateDB Protein IDBP-33034.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS12
Protein Name integrator complex subunit 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000340737
InnateDB Gene IDBG-33032 (INTS12)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID
InterPro IPR001965 Zinc finger, PHD-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
PFAM PF00628
PRINTS
PIRSF
SMART SM00249
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96CB8
PhosphoSite PhosphoSite-Q96CB8
TrEMBL E9PGI3
UniProt Splice Variant
Entrez Gene 57117
UniGene Hs.480454
RefSeq NP_065128
HUGO HGNC:25067
OMIM 611355
CCDS CCDS3671
HPRD 11271
IMGT
EMBL AC008243 AC093782 AC105391 AF242524 AK314939 BC014442 BK005729 CH471057
GenPept AAF99604 AAH14442 BAG37445 DAA05729 EAX06189 EAX06190