InnateDB Protein
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IDBP-33056.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PEMT
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Protein Name
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phosphatidylethanolamine N-methyltransferase
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Synonyms
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PEAMT; PEMPT; PEMT2; PNMT;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000255389
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InnateDB Gene
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IDBG-33054 (PEMT)
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Protein Structure
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Function |
Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000773
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phosphatidyl-N-methylethanolamine N-methyltransferase activity
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GO:0004608
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phosphatidylethanolamine N-methyltransferase activity
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GO:0008170
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N-methyltransferase activity
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GO:0080101
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phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007318
Phospholipid methyltransferase
IPR024960
Phosphatidyl-N-methylethanolamine/N-methyltransferase
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PFAM |
PF04191
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PRINTS |
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PIRSF |
PIRSF005444
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBM1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10400
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UniGene |
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RefSeq |
NP_680477
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HUGO |
HGNC:8830
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OMIM |
602391
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CCDS |
CCDS11186
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HPRD |
03862
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IMGT |
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EMBL |
AB029821
AC020558
AF113126
AF176806
AF176807
AF294463
AF294464
AF294465
AF294466
AF294467
AF294468
AK302251
BC000557
BC050593
CH471196
CR457099
EU574003
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GenPept |
AAD53291
AAD53292
AAF14867
AAH00557
AAH50593
AAK19172
ACB21050
BAA82407
BAG63603
CAG33380
EAW55701
EAW55702
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