Version 5.4
Homo sapiens Protein: TFCP2
Summary
InnateDB Protein IDBP-33114.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFCP2
Protein Name transcription factor CP2
Synonyms LBP1C; LSF; LSF1D; SEF; TFCP2C;
Species Homo sapiens
Ensembl Protein ENSP00000257915
InnateDB Gene IDBG-33112 (TFCP2)
Protein Structure
UniProt Annotation
Function Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. {ECO:0000250, ECO:0000269PubMed:10455131, ECO:0000269PubMed:1732747, ECO:0000269PubMed:8035790, ECO:0000269PubMed:8157699}.
Subcellular Localization Nucleus {ECO:0000269PubMed:1732747, ECO:0000269PubMed:7828600, ECO:0000269PubMed:8114710}.
Disease Associations
Tissue Specificity Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level). {ECO:0000269PubMed:10455131, ECO:0000269PubMed:7828600, ECO:0000269PubMed:8157699}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007604 CP2 transcription factor
IPR013761 Sterile alpha motif/pointed domain
PFAM PF04516
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q12800
PhosphoSite PhosphoSite-Q12800
TrEMBL F8VWL0
UniProt Splice Variant
Entrez Gene 7024
UniGene Hs.715085
RefSeq NP_005644
HUGO HGNC:11748
OMIM 189889
CCDS CCDS8808
HPRD 01790
IMGT
EMBL AC087884 AC139768 AK291264 BC003634 CH471111 M84810 U03494 U03495
GenPept AAA21324 AAA21325 AAH03634 BAF83953 EAW58174 EAW58175 EAW58178

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca