InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL22

Summary

InnateDB Protein

IDBP-33172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL22

Protein Name

chemokine (C-C motif) ligand 22

Synonyms

ABCD-1; DC/B-CK; MDC; SCYA22; STCP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000219235

InnateDB Gene

IDBG-33170 (CCL22)

Protein Structure

UniProt Annotation

Function

May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. {ECO:0000269PubMed:11241286}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	13 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0009615	response to virus
GO:0060326	cell chemotaxis