Homo sapiens Protein: CLDN15 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-33223.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CLDN15 | ||||||||||||||||||
Protein Name | claudin 15 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000308870 | ||||||||||||||||||
InnateDB Gene | IDBG-33221 (CLDN15) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake. {ECO:0000269PubMed:12055082, ECO:0000269PubMed:13129853}. | ||||||||||||||||||
Subcellular Localization | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Detected in colon (at protein level). {ECO:0000269PubMed:12055082}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR004031
PMP-22/EMP/MP20/Claudin superfamily IPR006187 Claudin IPR008094 Claudin-15 |
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PFAM |
PF00822
PF13903 |
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PRINTS |
PR01077
PR01718 |
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PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P56746 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P56746 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 24146 | ||||||||||||||||||
UniGene | Hs.38738 | ||||||||||||||||||
RefSeq | NP_055158 | ||||||||||||||||||
HUGO | HGNC:2036 | ||||||||||||||||||
OMIM | 615778 | ||||||||||||||||||
CCDS | CCDS5717 | ||||||||||||||||||
HPRD | 13065 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AJ245738 AK056103 CH471197 | ||||||||||||||||||
GenPept | BAG51627 CAB52587 EAW50211 | ||||||||||||||||||