InnateDB Protein
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IDBP-33241.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FKBP1B
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Protein Name
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FK506 binding protein 1B, 12.6 kDa
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Synonyms
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FKBP12.6; FKBP1L; OTK4; PKBP1L; PPIase;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000370379
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InnateDB Gene
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IDBG-33239 (FKBP1B)
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Protein Structure
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Function |
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. {ECO:0000269PubMed:10830164}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000413
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protein peptidyl-prolyl isomerization
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GO:0006457
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protein folding
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GO:0006458
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'de novo' protein folding
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GO:0010459
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negative regulation of heart rate
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GO:0010880
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regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
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GO:0010881
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regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
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GO:0022417
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protein maturation by protein folding
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GO:0032513
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negative regulation of protein phosphatase type 2B activity
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GO:0035584
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calcium-mediated signaling using intracellular calcium source
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GO:0042026
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protein refolding
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GO:0051280
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negative regulation of release of sequestered calcium ion into cytosol
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GO:0051284
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positive regulation of sequestering of calcium ion
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GO:0051480
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cytosolic calcium ion homeostasis
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GO:0051775
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response to redox state
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GO:0060314
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regulation of ryanodine-sensitive calcium-release channel activity
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GO:0060315
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negative regulation of ryanodine-sensitive calcium-release channel activity
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GO:0061077
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chaperone-mediated protein folding
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GO:0070588
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calcium ion transmembrane transport
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GO:0086064
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cell communication by electrical coupling involved in cardiac conduction
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Cellular Component |
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PDB ID |
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InterPro |
IPR001179
Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
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PFAM |
PF00254
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P68106
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
2281
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UniGene |
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RefSeq |
NP_473374
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HUGO |
HGNC:3712
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OMIM |
600620
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CCDS |
CCDS33153
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HPRD |
02795
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IMGT |
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EMBL |
AB190793
AC008073
AF322070
BC002614
CH471053
D38037
L37086
S69800
S69815
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GenPept |
AAB30684
AAB30685
AAC37581
AAH02614
AAK11191
AAY14663
BAA07232
BAE44300
EAX00769
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