InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FKBP1B

Summary

InnateDB Protein

IDBP-33243.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FKBP1B

Protein Name

FK506 binding protein 1B, 12.6 kDa

Synonyms

FKBP12.6; FKBP1L; OTK4; PKBP1L; PPIase;

Species

Homo sapiens

Ensembl Protein

ENSP00000370373

InnateDB Gene

IDBG-33239 (FKBP1B)

Protein Structure

UniProt Annotation

Function

Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Subcellular Localization

Cytoplasm {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. {ECO:0000269PubMed:10830164}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005102	receptor binding
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0019855	calcium channel inhibitor activity
GO:0030551	cyclic nucleotide binding
GO:0044325	ion channel binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0002027	regulation of heart rate
GO:0006457	protein folding
GO:0006458	'de novo' protein folding
GO:0006939	smooth muscle contraction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0009749	response to glucose
GO:0010033	response to organic substance
GO:0010459	negative regulation of heart rate
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019227	neuronal action potential propagation
GO:0022417	protein maturation by protein folding
GO:0030073	insulin secretion
GO:0032513	negative regulation of protein phosphatase type 2B activity
GO:0033197	response to vitamin E
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0042026	protein refolding
GO:0042098	T cell proliferation
GO:0042542	response to hydrogen peroxide
GO:0048680	positive regulation of axon regeneration
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051280	negative regulation of release of sequestered calcium ion into cytosol
GO:0051284	positive regulation of sequestering of calcium ion
GO:0051480	cytosolic calcium ion homeostasis
GO:0051775	response to redox state
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0061077	chaperone-mediated protein folding
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070588	calcium ion transmembrane transport
GO:0086064	cell communication by electrical coupling involved in cardiac conduction

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0016529	sarcoplasmic reticulum
GO:0030018	Z disc
GO:0033017	sarcoplasmic reticulum membrane
GO:0034704	calcium channel complex
GO:0043231	intracellular membrane-bounded organelle