InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALCA

Summary

InnateDB Protein

IDBP-33295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALCA

Protein Name

calcitonin-related polypeptide alpha

Synonyms

CALC1; CGRP; CGRP-I; CGRP1; CT; KC;

Species

Homo sapiens

Ensembl Protein

ENSP00000331746

InnateDB Gene

IDBG-33289 (CALCA)

Protein Structure

UniProt Annotation

Function

Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.Katacalcin is a potent plasma calcium-lowering peptide.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0031716	calcitonin receptor binding
GO:0042802	identical protein binding

Biological Process

GO:0001984	vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
GO:0002027	regulation of heart rate
GO:0002548	monocyte chemotaxis
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007566	embryo implantation
GO:0007568	aging
GO:0007631	feeding behavior
GO:0008016	regulation of heart contraction
GO:0009408	response to heat
GO:0030279	negative regulation of ossification
GO:0031645	negative regulation of neurological system process
GO:0032147	activation of protein kinase activity
GO:0042311	vasodilation
GO:0045087	innate immune response (InnateDB)
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045776	negative regulation of blood pressure
GO:0045778	positive regulation of ossification
GO:0045779	negative regulation of bone resorption
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045986	negative regulation of smooth muscle contraction
GO:0048265	response to pain
GO:0050727	regulation of inflammatory response
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0071356	cellular response to tumor necrosis factor
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton