Version 5.4
Homo sapiens Gene: CALCA
Summary
InnateDB Gene IDBG-33289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALCA
Gene Name calcitonin-related polypeptide alpha
Synonyms CALC1; CGRP; CGRP-I; CGRP1; CT; KC
Species Homo sapiens
Ensembl Gene ENSG00000110680
Encoded Proteins
IDBP-33291
calcitonin-related polypeptide alpha
IDBP-33295
calcitonin-related polypeptide alpha
IDBP-237648
calcitonin-related polypeptide alpha
IDBP-475273
calcitonin-related polypeptide alpha
IDBP-475030
calcitonin-related polypeptide alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20141542
CALCA can be produced by immune cells such as monocytes/macrophages following inflammatory stimulation and has a positive or negative reciprocal effect on the production of other pro- and anti-inflammatory mediators, playing both facilitating and suppressing roles in immune and inflammatory responses as shown in mice.
Entrez Gene
Summary This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:14966668-14972354
Strand Reverse strand
Band p15.2
Transcripts
ENST00000361010 ENSP00000354286
ENST00000331587 ENSP00000331746
ENST00000396372 ENSP00000379657
ENST00000486207 ENSP00000417833
ENST00000494746
ENST00000469608 ENSP00000420618
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0031716 calcitonin receptor binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
Biological Process
GO:0001935 endothelial cell proliferation
GO:0001944 vasculature development
GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure
GO:0001984 vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
GO:0002027 regulation of heart rate
GO:0002031 G-protein coupled receptor internalization
GO:0002548 monocyte chemotaxis
GO:0006468 protein phosphorylation
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0007159 leukocyte cell-cell adhesion
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0007566 embryo implantation
GO:0007568 aging
GO:0007631 feeding behavior
GO:0008016 regulation of heart contraction
GO:0008217 regulation of blood pressure
GO:0009408 response to heat
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0030279 negative regulation of ossification
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031623 receptor internalization
GO:0031645 negative regulation of neurological system process
GO:0032147 activation of protein kinase activity
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032757 positive regulation of interleukin-8 production
GO:0042311 vasodilation
GO:0043542 endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0045651 positive regulation of macrophage differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045776 negative regulation of blood pressure
GO:0045778 positive regulation of ossification
GO:0045779 negative regulation of bone resorption
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045909 positive regulation of vasodilation
GO:0045986 negative regulation of smooth muscle contraction
GO:0048265 response to pain
GO:0050727 regulation of inflammatory response
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0051480 cytosolic calcium ion homeostasis
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0071356 cellular response to tumor necrosis factor
GO:1990090 cellular response to nerve growth factor stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030424 axon
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000030669
View Gene Order
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18290
Calcitonin-like ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_75925
Amyloids pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P01258
TrEMBL
UniProt Splice Variant
Entrez Gene 796
UniGene Hs.37058 Hs.674137
RefSeq NM_001033952 NM_001033953 NM_001741 XM_005253134
HUGO HGNC:1437
OMIM 114130
CCDS CCDS31432 CCDS7819
HPRD 00238
IMGT
EMBL AC090835 BC069684 BC069704 BC069760 BC069778 BC093753 BC101599 BC143562 CH471064 DQ080435 K03513 M12664 M12665 M12666 M26095 M64486 X00356 X02330 X03662
GenPept AAA35501 AAA51913 AAA52124 AAA58403 AAH69684 AAH69704 AAH69760 AAH69778 AAH93753 AAI01600 AAI43563 AAY68212 CAA25103 CAA26189 CAA27299 EAW68468
RNA Seq Atlas 796

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca