InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCKIPSD

Summary

InnateDB Protein

IDBP-33346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCKIPSD

Protein Name

NCK interacting protein with SH3 domain

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000294129

InnateDB Gene

IDBG-239383 (NCKIPSD)

Protein Structure

UniProt Annotation

Function

Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP- induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269PubMed:22419821}.

Subcellular Localization

Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.

Disease Associations

Note=A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with KMT2A/MLL1.

Tissue Specificity

Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen. {ECO:0000269PubMed:10619843}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0006607	NLS-bearing protein import into nucleus
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response