Version 5.4
Homo sapiens Gene: NCKIPSD
Summary
InnateDB Gene IDBG-239383.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCKIPSD
Gene Name NCK interacting protein with SH3 domain
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213672
Encoded Proteins
IDBP-33346
NCK interacting protein with SH3 domain
IDBP-376430
NCK interacting protein with SH3 domain
IDBP-376432
NCK interacting protein with SH3 domain
IDBP-376434
NCK interacting protein with SH3 domain
IDBP-376438
NCK interacting protein with SH3 domain
IDBP-376443
NCK interacting protein with SH3 domain
IDBP-376445
NCK interacting protein with SH3 domain
IDBP-376447
NCK interacting protein with SH3 domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:48673844-48686364
Strand Reverse strand
Band p21.31
Transcripts
ENST00000294129 ENSP00000294129
ENST00000416649 ENSP00000389059
ENST00000413374 ENSP00000396683
ENST00000415281 ENSP00000406442
ENST00000439518 ENSP00000409675
ENST00000454134 ENSP00000416144
ENST00000426678 ENSP00000416904
ENST00000453349 ENSP00000408588
ENST00000470006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0006607 NLS-bearing protein import into nucleus
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
Cellular Component
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0008180 COP9 signalosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032598
View Gene Order
ENSBTAG00000021850
Not yet available
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655006
RefSeq NM_016453 NM_184231 XM_005265223
HUGO
OMIM
CCDS CCDS2776 CCDS46827
HPRD 09450
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca