InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2U1

Summary

InnateDB Protein

IDBP-33400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2U1

Protein Name

cytochrome P450, family 2, subfamily U, polypeptide 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000333212

InnateDB Gene

IDBG-33398 (CYP2U1)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. {ECO:0000269PubMed:14660610}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:14660610}; Multi-pass membrane protein {ECO:0000269PubMed:14660610}. Microsome membrane {ECO:0000269PubMed:14660610}.

Disease Associations

Spastic paraplegia 56, autosomal recessive (SPG56) [MIM:615030]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations. In SPG56, upper limbs are often also affected. Some SPG56 patients may have a subclinical axonal neuropathy. {ECO:0000269PubMed:23176821}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed with stronger expression in thymus, heart and cerebellum. {ECO:0000269PubMed:14660610, ECO:0000269PubMed:14975754, ECO:0000269PubMed:15752708}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008219	cell death
GO:0019369	arachidonic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0097267	omega-hydroxylase P450 pathway

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008069 Cytochrome P450, E-class, group I, CYP2D-like

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00465
PR01686

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7Z449