Version 5.4
Homo sapiens Protein: INSC
Summary
InnateDB Protein IDBP-33448.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INSC
Protein Name inscuteable homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000368872
InnateDB Gene IDBG-33444 (INSC)
Protein Structure
UniProt Annotation
Function May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium. {ECO:0000269PubMed:16458856}.
Subcellular Localization Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas. {ECO:0000269PubMed:12469229, ECO:0000269PubMed:16458856}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0007399 nervous system development
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID
InterPro IPR000225 Armadillo
IPR016024 Armadillo-type fold
PFAM PF00514
PRINTS
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1MX18
PhosphoSite PhosphoSite-Q1MX18
TrEMBL
UniProt Splice Variant
Entrez Gene 387755
UniGene Hs.591997
RefSeq NP_001027024
HUGO HGNC:33116
OMIM 610668
CCDS CCDS41621
HPRD
IMGT
EMBL AB231744 AB231745 AB231746 AB231747 AB231748 AB236158 AB236159 AC090744 BC127700
GenPept AAI27701 BAE17133 BAE17134 BAE17135 BAE17136 BAE46891 BAE93463 BAE93464

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca