Version 5.4
Homo sapiens Gene: INSC
Summary
InnateDB Gene IDBG-33444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INSC
Gene Name inscuteable homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188487
Encoded Proteins
IDBP-33446
inscuteable homolog (Drosophila)
IDBP-33448
inscuteable homolog (Drosophila)
IDBP-367528
inscuteable homolog (Drosophila)
IDBP-591969
inscuteable homolog (Drosophila)
IDBP-592140
inscuteable homolog (Drosophila)
IDBP-587340
inscuteable homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:15112424-15247208
Strand Forward strand
Band p15.2
Transcripts
ENST00000379556 ENSP00000368874
ENST00000379554 ENSP00000368872
ENST00000424273 ENSP00000389161
ENST00000447214
ENST00000528567 ENSP00000435022
ENST00000530161 ENSP00000436194
ENST00000525218 ENSP00000436113
ENST00000526102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0007399 nervous system development
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048782
View Gene Order
ENSBTAG00000032782
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591997
RefSeq NM_001031853 NM_001042536 NM_001278313 NM_001278314 NM_001278315 NM_001278316 XM_006718227
HUGO
OMIM
CCDS CCDS41621 CCDS41622 CCDS60735 CCDS60736
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca