Version 5.4
Homo sapiens Protein: PFN4
Summary
InnateDB Protein IDBP-33557.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFN4
Protein Name profilin family, member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000322170
InnateDB Gene IDBG-33553 (PFN4)
Protein Structure
UniProt Annotation
Function Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin (PubMed:19419568), contrary to other family members. {ECO:0000269PubMed:19419568}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in testis (at protein level). {ECO:0000269PubMed:15591451}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008289 lipid binding
Biological Process
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR005455 Profilin
PFAM PF00235
PRINTS PR00392
PR01640
PIRSF
SMART SM00392
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NHR9
PhosphoSite PhosphoSite-Q8NHR9
TrEMBL
UniProt Splice Variant
Entrez Gene 375189
UniGene
RefSeq NP_955378
HUGO HGNC:31103
OMIM
CCDS CCDS1709
HPRD 15120
IMGT
EMBL AC008073 AK292601 BC029523 CH471053
GenPept AAH29523 AAY14666 BAF85290 EAX00760 EAX00761

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca