InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITSN2

Summary

InnateDB Protein

IDBP-33604.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITSN2

Protein Name

intersectin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354561

InnateDB Gene

IDBG-33600 (ITSN2)

Protein Structure

UniProt Annotation

Function

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). {ECO:0000269PubMed:19458185, ECO:0000269PubMed:22648170}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.

Experimentally validated
Total	86 [view]
Protein-Protein	86 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006897	endocytosis
GO:0009967	positive regulation of signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000219 Dbl homology (DH) domain
IPR000261 EPS15 homology (EH)
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain

PFAM