Version 5.4
Homo sapiens Protein: PLEKHA7
Summary
InnateDB Protein IDBP-33617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHA7
Protein Name pleckstrin homology domain containing, family A member 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000347883
InnateDB Gene IDBG-33615 (PLEKHA7)
Protein Structure
UniProt Annotation
Function Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. {ECO:0000269PubMed:19041755}.
Subcellular Localization Cell junction, adherens junction {ECO:0000269PubMed:19041755}. Cytoplasm {ECO:0000269PubMed:19041755}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:19041755}. Note=Localizes to zonula adherens, recruited via its interaction with CTNND1.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0070097 delta-catenin binding
Biological Process
GO:0045218 zonula adherens maintenance
GO:0090136 epithelial cell-cell adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005915 zonula adherens
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001202 WW domain
IPR001849 Pleckstrin homology domain
PFAM PF00397
PF00169
PRINTS
PIRSF
SMART SM00456
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6IQ23
PhosphoSite PhosphoSite-Q6IQ23
TrEMBL E9PL74
UniProt Splice Variant
Entrez Gene 144100
UniGene Hs.739092
RefSeq NP_778228
HUGO HGNC:27049
OMIM 612686
CCDS CCDS31434
HPRD 15142
IMGT
EMBL AC026639 AC116533 AC127033 AC131064 AK296371 AK301465 BC033239 BC071599
GenPept AAH33239 AAH71599 BAG59045 BAG62985

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca