InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF11B

Summary

InnateDB Protein

IDBP-33677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF11B

Protein Name

tumor necrosis factor receptor superfamily, member 11b

Synonyms

OCIF; OPG; TR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000297350

InnateDB Gene

IDBG-33675 (TNFRSF11B)

Protein Structure

UniProt Annotation

Function

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269PubMed:22664871, ECO:0000269PubMed:9168977}.

Subcellular Localization

Secreted.

Disease Associations

Juvenile Paget disease (JPD) [MIM:239000]: Rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal. {ECO:0000269PubMed:12189164}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005125	cytokine activity
GO:0005515	protein binding

Biological Process

GO:0001501	skeletal system development
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007584	response to nutrient
GO:0010035	response to inorganic substance
GO:0030198	extracellular matrix organization
GO:0032026	response to magnesium ion
GO:0042489	negative regulation of odontogenesis of dentin-containing tooth
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0045779	negative regulation of bone resorption
GO:0046685	response to arsenic-containing substance

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000488 Death domain
IPR001368 TNFR/NGFR cysteine-rich region
IPR011029 Death-like domain
IPR017371 Tumour necrosis factor receptor 11B
IPR022323 Tumour necrosis factor receptor 11

PFAM

PF00531
PF00020

PRINTS

PR01975
PR01961

PIRSF

PIRSF038065

SMART

SM00005
SM00208

TIGRFAMs

Post-translational Modifications

Modification

Cross-References