InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FLII

Summary

InnateDB Protein

IDBP-33700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FLII

Protein Name

flightless I homolog (Drosophila)

Synonyms

FLI; Fli1; FLIL;

Species

Homo sapiens

Ensembl Protein

ENSP00000324573

InnateDB Gene

IDBG-33698 (FLII)

Protein Structure

UniProt Annotation

Function

May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. {ECO:0000250, ECO:0000269PubMed:14966289}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongest expression in skeletal muscle with high expression also in the heart and lung. {ECO:0000269PubMed:9525888}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006936	muscle contraction
GO:0007275	multicellular organismal development