InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASA4

Summary

InnateDB Protein

IDBP-33798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASA4

Protein Name

RAS p21 protein activator 4

Synonyms

CAPRI; GAPL;

Species

Homo sapiens

Ensembl Protein

ENSP00000262940

InnateDB Gene

IDBG-33794 (RASA4)

Protein Structure

UniProt Annotation

Function

Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269PubMed:11448776}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:11448776}. Cell membrane {ECO:0000269PubMed:11448776}; Peripheral membrane protein {ECO:0000269PubMed:11448776}. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11448776}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein

PFAM

PF00168
PF00779
PF00169
PF00616

PRINTS

PR00360
PR00402

PIRSF

SMART

SM00239
SM00107
SM00233
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt