InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RASA4

Summary

InnateDB Gene

IDBG-33794.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASA4

Gene Name

RAS p21 protein activator 4

Synonyms

CAPRI; GAPL

Species

Homo sapiens

Ensembl Gene

ENSG00000105808

Encoded Proteins

IDBP-33798

RAS p21 protein activator 4

IDBP-384385

RAS p21 protein activator 4

IDBP-481675

RAS p21 protein activator 4

IDBP-473523

RAS p21 protein activator 4

IDBP-475913

RAS p21 protein activator 4

IDBP-478009

RAS p21 protein activator 4

IDBP-479545

RAS p21 protein activator 4

IDBP-483728

RAS p21 protein activator 4

IDBP-474441

RAS p21 protein activator 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:102573807-102616757

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000262940	ENSP00000262940
ENST00000449970	ENSP00000412876
ENST00000461209	ENSP00000420352
ENST00000522223
ENST00000462172	ENSP00000417395
ENST00000523568
ENST00000521822
ENST00000521397	ENSP00000428605
ENST00000520577
ENST00000519539	ENSP00000430337
ENST00000522801	ENSP00000430418
ENST00000519878
ENST00000520042	ENSP00000428732
ENST00000521076	ENSP00000428448
ENST00000522443
ENST00000521892

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004952

View Gene Order

ENSBTAG00000005448

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

ras_pathway

Regulation of Ras family activation

Cross-References

SwissProt

O43374

TrEMBL

B4DWS8 E5RGQ8 E5RID2 E5RK78 E7ERK1

UniProt Splice Variant

Entrez Gene

102724229

UniGene

Hs.649203 Hs.670011 Hs.696339 Hs.701222 Hs.729352

RefSeq

NM_001079877 NM_006989 XM_006715828 XM_006715829

HUGO

HGNC:23181

OMIM

607943

CCDS

CCDS47674 CCDS5725

HPRD

IMGT

EMBL

AB011110 AC004084 AC093668 AC105052 AK026441 AK301666 AY029206 BC113663

GenPept

AAB97935 AAI13664 AAK31582 AAP22345 BAA25464 BAG63140

RNA Seq Atlas

10156 102724229