InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNJ11

Summary

InnateDB Protein

IDBP-33835.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ11

Protein Name

potassium inwardly-rectifying channel, subfamily J, member 11

Synonyms

BIR; HHF2; IKATP; KIR6.2; PHHI; TNDM3;

Species

Homo sapiens

Ensembl Protein

ENSP00000345708

InnateDB Gene

IDBG-33833 (KCNJ11)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0015272	ATP-activated inward rectifier potassium channel activity
GO:0030506	ankyrin binding
GO:0030955	potassium ion binding
GO:0031072	heat shock protein binding
GO:0044325	ion channel binding

Biological Process

GO:0002931	response to ischemia
GO:0006006	glucose metabolic process
GO:0006112	energy reserve metabolic process
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0010107	potassium ion import
GO:0032355	response to estradiol
GO:0033198	response to ATP
GO:0033574	response to testosterone
GO:0042391	regulation of membrane potential
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0046676	negative regulation of insulin secretion
GO:0050796	regulation of insulin secretion
GO:0050877	neurological system process
GO:0071316	cellular response to nicotine
GO:0071333	cellular response to glucose stimulus
GO:0071356	cellular response to tumor necrosis factor
GO:0071805	potassium ion transmembrane transport
GO:2001259	positive regulation of cation channel activity

Cellular Component

GO:0005635	nuclear envelope
GO:0005739	mitochondrion
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0008282	ATP-sensitive potassium channel complex
GO:0014704	intercalated disc
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0030673	axolemma
GO:0042383	sarcolemma
GO:0043025	neuronal cell body
GO:0043209	myelin sheath
GO:0043231	intracellular membrane-bounded organelle
GO:0070852	cell body fiber