InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARIH2

Summary

InnateDB Protein

IDBP-33856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARIH2

Protein Name

ariadne homolog 2 (Drosophila)

Synonyms

ARI2; TRIAD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000348769

InnateDB Gene

IDBG-33854 (ARIH2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys- 63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis. {ECO:0000269PubMed:16118314, ECO:0000269PubMed:17646546, ECO:0000269PubMed:19340006}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in granulocytes. {ECO:0000269PubMed:16118314}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007275	multicellular organismal development
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0048588	developmental cell growth
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0071425	hematopoietic stem cell proliferation