InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SHMT1

Summary

InnateDB Protein

IDBP-33956.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHMT1

Protein Name

serine hydroxymethyltransferase 1 (soluble)

Synonyms

CSHMT; SHMT;

Species

Homo sapiens

Ensembl Protein

ENSP00000318868

InnateDB Gene

IDBG-33954 (SHMT1)

Protein Structure

UniProt Annotation

Function

Interconversion of serine and glycine.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004372	glycine hydroxymethyltransferase activity
GO:0008732	L-allo-threonine aldolase activity
GO:0016597	amino acid binding
GO:0030170	pyridoxal phosphate binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006544	glycine metabolic process
GO:0006545	glycine biosynthetic process
GO:0006563	L-serine metabolic process
GO:0006565	L-serine catabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009058	biosynthetic process
GO:0009113	purine nucleobase biosynthetic process
GO:0019264	glycine biosynthetic process from serine
GO:0034641	cellular nitrogen compound metabolic process
GO:0035999	tetrahydrofolate interconversion
GO:0044281	small molecule metabolic process
GO:0045329	carnitine biosynthetic process
GO:0046655	folic acid metabolic process
GO:0051262	protein tetramerization
GO:0051289	protein homotetramerization