InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SHMT1

Summary

InnateDB Gene

IDBG-33954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHMT1

Gene Name

serine hydroxymethyltransferase 1 (soluble)

Synonyms

CSHMT; SHMT

Species

Homo sapiens

Ensembl Gene

ENSG00000176974

Encoded Proteins

IDBP-33956

serine hydroxymethyltransferase 1 (soluble)

IDBP-33958

serine hydroxymethyltransferase 1 (soluble)

IDBP-33960

serine hydroxymethyltransferase 1 (soluble)

IDBP-760937

IDBP-758897

IDBP-763047

IDBP-813442

serine hydroxymethyltransferase 1 (soluble)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:18327860-18363563

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000316694	ENSP00000318868
ENST00000354098	ENSP00000318805
ENST00000352886	ENSP00000345881
ENST00000395684
ENST00000395682
ENST00000579558
ENST00000583780	ENSP00000462041
ENST00000582653	ENSP00000462227
ENST00000580002	ENSP00000462043
ENST00000582352
ENST00000618902	ENSP00000477782

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004372	glycine hydroxymethyltransferase activity
GO:0008242	omega peptidase activity
GO:0008732	L-allo-threonine aldolase activity
GO:0016597	amino acid binding
GO:0030170	pyridoxal phosphate binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006508	proteolysis
GO:0006544	glycine metabolic process
GO:0006545	glycine biosynthetic process
GO:0006563	L-serine metabolic process
GO:0006565	L-serine catabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009058	biosynthetic process
GO:0009113	purine nucleobase biosynthetic process
GO:0019264	glycine biosynthetic process from serine
GO:0034641	cellular nitrogen compound metabolic process
GO:0035999	tetrahydrofolate interconversion
GO:0044281	small molecule metabolic process
GO:0045329	carnitine biosynthetic process
GO:0046655	folic acid metabolic process
GO:0051262	protein tetramerization
GO:0051289	protein homotetramerization