Version 5.4
Homo sapiens Protein: SHMT1
Summary
InnateDB Protein IDBP-33958.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHMT1
Protein Name serine hydroxymethyltransferase 1 (soluble)
Synonyms CSHMT; SHMT;
Species Homo sapiens
Ensembl Protein ENSP00000318805
InnateDB Gene IDBG-33954 (SHMT1)
Protein Structure
UniProt Annotation
Function Interconversion of serine and glycine.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004372 glycine hydroxymethyltransferase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006544 glycine metabolic process
GO:0006563 L-serine metabolic process
GO:0006565 L-serine catabolic process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0009113 purine nucleobase biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0035999 tetrahydrofolate interconversion
GO:0044281 small molecule metabolic process
GO:0045329 carnitine biosynthetic process
GO:0046655 folic acid metabolic process
GO:0051262 protein tetramerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001085 Serine hydroxymethyltransferase
IPR015424 Pyridoxal phosphate-dependent transferase
PFAM PF00464
PRINTS
PIRSF PIRSF000412
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P34896
PhosphoSite PhosphoSite-P34896
TrEMBL Q9UMC9
UniProt Splice Variant
Entrez Gene 6470
UniGene Hs.736265
RefSeq NP_683718
HUGO HGNC:10850
OMIM 182144
CCDS CCDS11197
HPRD 01643
IMGT
EMBL AC127537 AK298415 AL353997 BC007979 BC022874 BC038598 CH471196 L11931 L23928 Y14485 Y14486 Y14487 Y14489
GenPept AAA36018 AAA36019 AAA36020 AAA63257 AAH07979 AAH22874 AAH38598 BAG60641 CAB54838 CAB54839 CAB54840 CAB54842 EAW55637 EAW55640 EAW55641

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca