Version 5.4
Homo sapiens Protein: CENPO
Summary
InnateDB Protein IDBP-34050.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CENPO
Protein Name centromere protein O
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000260662
InnateDB Gene IDBG-34046 (CENPO)
Protein Structure
UniProt Annotation
Function Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. {ECO:0000269PubMed:16622420, ECO:0000269PubMed:16716197, ECO:0000269PubMed:16932742, ECO:0000269PubMed:18007590}.
Subcellular Localization Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 14 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000278 mitotic cell cycle
GO:0006334 nucleosome assembly
GO:0034080 centromere-specific nucleosome assembly
GO:0034508 centromere complex assembly
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR018464 Centromere protein O
PFAM PF09496
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BU64
PhosphoSite PhosphoSite-Q9BU64
TrEMBL
UniProt Splice Variant
Entrez Gene 79172
UniGene Hs.732476
RefSeq NP_077298
HUGO HGNC:28152
OMIM 611504
CCDS CCDS1714
HPRD 14414
IMGT
EMBL AC012073 AC013459 AK027859 AK315483 BC002870 CH471053
GenPept AAH02870 AAY14786 BAB55414 BAG37867 EAX00742 EAX00743

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca