InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP15

Summary

InnateDB Protein

IDBP-34056.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP15

Protein Name

matrix metallopeptidase 15 (membrane-inserted)

Synonyms

MT2-MMP; MTMMP2; SMCP-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000219271

InnateDB Gene

IDBG-34054 (MMP15)

Protein Structure

UniProt Annotation

Function

Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. {ECO:0000269PubMed:9461298}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}.

Disease Associations

Tissue Specificity

Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0032355	response to estradiol
GO:0043085	positive regulation of catalytic activity

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A
IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal

PFAM

PF00413
PF01471
PF00045
PF11857

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References