InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MMP15

Summary

InnateDB Gene

IDBG-34054.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP15

Gene Name

matrix metallopeptidase 15 (membrane-inserted)

Synonyms

MT2-MMP; MTMMP2; SMCP-2

Species

Homo sapiens

Ensembl Gene

ENSG00000102996

Encoded Proteins

IDBP-34056

matrix metallopeptidase 15 (membrane-inserted)

IDBP-751079

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:58025566-58046901

Strand

Forward strand

Band

q21

Transcripts

ENST00000219271	ENSP00000219271
ENST00000570065	ENSP00000457084

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0032355	response to estradiol
GO:0043085	positive regulation of catalytic activity

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0031012	extracellular matrix

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_118682

Activation of Matrix Metalloproteinases pathway

REACT_150401

Collagen degradation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P51511

TrEMBL

A0A024R6U8

UniProt Splice Variant

Entrez Gene

4324

UniGene

Hs.80343

RefSeq

NM_002428

HUGO

HGNC:7161

OMIM

602261

CCDS

CCDS10792

HPRD

IMGT

EMBL

BC036495 BC055428 CH471092 D85510 D86331 EF032329 Z48482

GenPept

AAH36495 AAH55428 ABJ53423 BAA13071 BAA22225 CAA88373 EAW82965 EAW82966

RNA Seq Atlas

4324