Version 5.4
Homo sapiens Protein: SLC1A6
Summary
InnateDB Protein IDBP-34072.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC1A6
Protein Name solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms EAAT4;
Species Homo sapiens
Ensembl Protein ENSP00000221742
InnateDB Gene IDBG-34070 (SLC1A6)
Protein Structure
UniProt Annotation
Function Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Brain. Expressed densely and selectively in cell bodies of Purkinje cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0017153 sodium:dicarboxylate symporter activity
Biological Process
GO:0006811 ion transport
GO:0006835 dicarboxylic acid transport
GO:0007268 synaptic transmission
GO:0015810 aspartate transport
GO:0015813 L-glutamate transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001991 Sodium:dicarboxylate symporter
PFAM PF00375
PRINTS PR00173
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P48664
PhosphoSite PhosphoSite-P48664
TrEMBL M0R1V3
UniProt Splice Variant
Entrez Gene 6511
UniGene Hs.515217
RefSeq NP_005062
HUGO HGNC:10944
OMIM 600637
CCDS CCDS12321
HPRD 09005
IMGT
EMBL AC004659 AC104528 BC028721 BC040604 U18244
GenPept AAA75314 AAC15754 AAH28721 AAH40604

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca