Version 5.4
Homo sapiens Protein: NAPEPLD
Summary
InnateDB Protein IDBP-34191.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAPEPLD
Protein Name N-acyl phosphatidylethanolamine phospholipase D
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000340093
InnateDB Gene IDBG-34189 (NAPEPLD)
Protein Structure
UniProt Annotation
Function Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
Biological Process
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
Cellular Component
GO:0042622 photoreceptor outer segment membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001279 Beta-lactamase-like
PFAM PF00753
PRINTS
PIRSF
SMART SM00849
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6IQ20
PhosphoSite PhosphoSite-Q6IQ20
TrEMBL J3KR15
UniProt Splice Variant
Entrez Gene 222236
UniGene Hs.707586
RefSeq NP_945341
HUGO HGNC:21683
OMIM 612334
CCDS CCDS5729
HPRD 14809
IMGT
EMBL AB112352 AC007683 AY357337 BC071604 CH471070 CR936639
GenPept AAH71604 AAR13673 BAD02399 CAI56779 EAW83314

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca