Version 5.4
Homo sapiens Gene: NAPEPLD
Summary
InnateDB Gene IDBG-34189.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAPEPLD
Gene Name N-acyl phosphatidylethanolamine phospholipase D
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161048
Encoded Proteins
IDBP-34191
N-acyl phosphatidylethanolamine phospholipase D
IDBP-384492
N-acyl phosphatidylethanolamine phospholipase D
IDBP-384494
N-acyl phosphatidylethanolamine phospholipase D
IDBP-384495
N-acyl phosphatidylethanolamine phospholipase D
IDBP-384497
N-acyl phosphatidylethanolamine phospholipase D
IDBP-384498
N-acyl phosphatidylethanolamine phospholipase D
IDBP-384499
N-acyl phosphatidylethanolamine phospholipase D
IDBP-481153
N-acyl phosphatidylethanolamine phospholipase D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:103099776-103149560
Strand Reverse strand
Band q22.1
Transcripts
ENST00000341533 ENSP00000340093
ENST00000414118
ENST00000417955 ENSP00000407112
ENST00000422589 ENSP00000412376
ENST00000420631 ENSP00000395138
ENST00000427257 ENSP00000392775
ENST00000418294 ENSP00000404391
ENST00000425379 ENSP00000414778
ENST00000465647 ENSP00000419188
ENST00000479761
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004620 phospholipase activity
GO:0008270 zinc ion binding
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
Biological Process
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
Cellular Component
GO:0042622 photoreceptor outer segment membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044968
View Gene Order
ENSBTAG00000014171
Not yet available
Pathways
NETPATH
REACTOME
REACT_160156
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_160194
Biosynthesis of A2E, implicated in retinal degradation pathway
REACT_160130
Retinoid cycle disease events pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.324271 Hs.627902 Hs.690825 Hs.699563 Hs.707586
RefSeq NM_001122838 NM_198990 XM_005250214 XM_006725053
HUGO
OMIM
CCDS CCDS5729
HPRD 14809
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca