Version 5.4
Homo sapiens Protein: SYDE1
Summary
InnateDB Protein IDBP-34194.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYDE1
Protein Name synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000341489
InnateDB Gene IDBG-34192 (SYDE1)
Protein Structure
UniProt Annotation
Function GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0007130 synaptonemal complex assembly
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0016081 synaptic vesicle docking involved in exocytosis
GO:0032862 activation of Rho GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0050806 positive regulation of synaptic transmission
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0044300 cerebellar mossy fiber
GO:0097060 synaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000198 Rho GTPase-activating protein domain
IPR008936 Rho GTPase activation protein
PFAM PF00168
PF00620
PRINTS PR00360
PIRSF
SMART SM00239
SM00324
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZW31
PhosphoSite PhosphoSite-Q6ZW31
TrEMBL
UniProt Splice Variant
Entrez Gene 85360
UniGene Hs.732011
RefSeq NP_149014
HUGO HGNC:25824
OMIM
CCDS CCDS12324
HPRD 07830
IMGT
EMBL AK023573 AK123686 BC018942 BC029926 CH471106
GenPept AAH18942 AAH29926 BAB14612 BAC85676 EAW84462 EAW84463

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca