InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTBP

Summary

InnateDB Protein

IDBP-34286.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTBP

Protein Name

Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000303398

InnateDB Gene

IDBG-34284 (MTBP)

Protein Structure

UniProt Annotation

Function

Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269PubMed:15632057}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007050	cell cycle arrest
GO:0007089	traversing start control point of mitotic cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0034501	protein localization to kinetochore
GO:0071174	mitotic spindle checkpoint