Version 5.4
Homo sapiens Gene: MTBP
Summary
InnateDB Gene IDBG-34284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTBP
Gene Name Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172167
Encoded Proteins
IDBP-34286
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
IDBP-479870
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
IDBP-479778
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:120445400-120542133
Strand Forward strand
Band q24.12
Transcripts
ENST00000305949 ENSP00000303398
ENST00000456899
ENST00000522308
ENST00000523373 ENSP00000430771
ENST00000522449
ENST00000519188
ENST00000519556 ENSP00000428574
ENST00000519841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007050 cell cycle arrest
GO:0007089 traversing start control point of mitotic cell cycle
GO:0008285 negative regulation of cell proliferation
GO:0034501 protein localization to kinetochore
GO:0071174 mitotic spindle checkpoint
Cellular Component
GO:0000776 kinetochore
GO:0000785 chromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022369
View Gene Order
ENSBTAG00000006770
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.657656
RefSeq NM_022045
HUGO
OMIM
CCDS CCDS6333
HPRD 12068
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca