InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: QARS

Summary

InnateDB Protein

IDBP-34289.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

QARS

Protein Name

glutaminyl-tRNA synthetase

Synonyms

GLNRS; MSCCA; PRO2195;

Species

Homo sapiens

Ensembl Protein

ENSP00000307567

InnateDB Gene

IDBG-34287 (QARS)

Protein Structure

UniProt Annotation

Function

Plays a critical role in brain development. {ECO:0000269PubMed:24656866}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:24656866}.

Disease Associations

Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA) [MIM:615760]: A severe, autosomal recessive, neurodevelopmental and neurodegenerative disorder characterized by progressive microcephaly, severe seizures in infancy, atrophy of the cerebral cortex and cerebellar vermis, and mild atrophy of the cerebellar hemispheres, resulting in profoundly delayed development and hypotonia. {ECO:0000269PubMed:24656866}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate. {ECO:0000269PubMed:24656866}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.

Experimentally validated
Total	120 [view]
Protein-Protein	120 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004819	glutamine-tRNA ligase activity
GO:0005524	ATP binding
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds

Biological Process

GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006425	glutaminyl-tRNA aminoacylation
GO:0010467	gene expression
GO:0043039	tRNA aminoacylation

Cellular Component

GO:0005737	cytoplasm
GO:0005759	mitochondrial matrix
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000924 Glutamyl/glutaminyl-tRNA synthetase
IPR004514 Glutamine-tRNA synthetase
IPR007638 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2
IPR007639 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal
IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain

PFAM

PF04557
PF04558
PF00749
PF03950

PRINTS

PR00987

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P47897