InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAJC2

Summary

InnateDB Protein

IDBP-34316.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJC2

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368565

InnateDB Gene

IDBG-34312 (DNAJC2)

Protein Structure

UniProt Annotation

Function

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. {ECO:0000269PubMed:15802566, ECO:0000269PubMed:16002468, ECO:0000269PubMed:21179169}.

Subcellular Localization

Nucleus. Cytoplasm, cytosol.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11034098}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0030544	Hsp70 protein binding
GO:0042393	histone binding
GO:0043130	ubiquitin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0016568	chromatin modification
GO:0030308	negative regulation of cell growth
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051083	'de novo' cotranslational protein folding
GO:2000279	negative regulation of DNA biosynthetic process