InnateDB Protein
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IDBP-3437.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SKA1
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Protein Name
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spindle and kinetochore associated complex subunit 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000285116
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InnateDB Gene
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IDBG-3435 (SKA1)
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Protein Structure
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Function |
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules. {ECO:0000269PubMed:17093495, ECO:0000269PubMed:19289083}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. Associates with kinetochores following microtubule attachment from prometaphase, through mid- anaphase and then vanishes in telophase.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009829
Protein of unknown function DUF1395
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PFAM |
PF07160
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96BD8
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PhosphoSite |
PhosphoSite-Q96BD8
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TrEMBL |
K7EPW0
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UniProt Splice Variant |
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Entrez Gene |
220134
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UniGene |
Hs.134726
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RefSeq |
NP_659497
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HUGO |
HGNC:28109
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OMIM |
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CCDS |
CCDS11946
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HPRD |
12689
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IMGT |
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EMBL |
AC105227
AK303464
AK313968
BC015706
CH471096
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GenPept |
AAH15706
BAG36683
BAG64506
EAW62971
EAW62972
EAW62973
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