InnateDB Protein
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IDBP-34408.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC26A5
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Protein Name
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solute carrier family 26, member 5 (prestin)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349210
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InnateDB Gene
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IDBG-34404 (SLC26A5)
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Protein Structure
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Function |
Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage- to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Lateral wall of outer hair cells. {ECO:0000250}.
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Disease Associations |
Deafness, autosomal recessive, 61 (DFNB61) [MIM:613865]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:12719379}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0008271
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secondary active sulfate transmembrane transporter activity
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GO:0015116
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sulfate transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011547
Sulphate transporter
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PFAM |
PF00916
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P58743
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PhosphoSite |
PhosphoSite-P58743
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
375611
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UniGene |
Hs.585146
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RefSeq |
NP_996768
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HUGO |
HGNC:9359
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OMIM |
604943
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CCDS |
CCDS5732
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HPRD |
09224
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IMGT |
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EMBL |
AC004668
AC005064
AC093701
AF523354
AY256823
AY256824
AY256825
AY289134
BC100833
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GenPept |
AAI00834
AAP31417
AAP31532
AAP31533
AAP31534
AAP43686
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