InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DERL1

Summary

InnateDB Protein

IDBP-34431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DERL1

Protein Name

Der1-like domain family, member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000259512

InnateDB Gene

IDBG-34429 (DERL1)

Protein Structure

UniProt Annotation

Function

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. {ECO:0000269PubMed:15215855, ECO:0000269PubMed:15215856}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15215855, ECO:0000269PubMed:15215856, ECO:0000269PubMed:16186509, ECO:0000269PubMed:16449189}; Multi- pass membrane protein {ECO:0000269PubMed:15215855, ECO:0000269PubMed:15215856, ECO:0000269PubMed:16186509, ECO:0000269PubMed:16449189}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:15215855, ECO:0000269PubMed:16449189}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	57 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0042288	MHC class I protein binding

Biological Process

GO:0006986	response to unfolded protein
GO:0019060	intracellular transport of viral protein in host cell
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0030970	retrograde protein transport, ER to cytosol
GO:0034620	cellular response to unfolded protein
GO:0045184	establishment of protein localization

Cellular Component

GO:0000836	Hrd1p ubiquitin ligase complex
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane