InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP4

Summary

InnateDB Protein

IDBP-34597.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP4

Protein Name

ubiquitin specific peptidase 4 (proto-oncogene)

Synonyms

UNP; Unph;

Species

Homo sapiens

Ensembl Protein

ENSP00000265560

InnateDB Gene

IDBG-34595 (USP4)

Protein Structure

UniProt Annotation

Function

Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER. {ECO:0000269PubMed:16316627, ECO:0000269PubMed:16339847, ECO:0000269PubMed:16472766, ECO:0000269PubMed:7784062}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons. {ECO:0000269PubMed:16339847, ECO:0000269PubMed:7784062}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	102 [view]
Protein-Protein	99 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0031685	adenosine receptor binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016579	protein deubiquitination
GO:0031397	negative regulation of protein ubiquitination
GO:0031647	regulation of protein stability
GO:0034394	protein localization to cell surface
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00443
PF06337

PRINTS

PIRSF

SMART

SM00695

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13107