Version 5.4
Homo sapiens Gene: USP4
Summary
InnateDB Gene IDBG-34595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP4
Gene Name ubiquitin specific peptidase 4 (proto-oncogene)
Synonyms UNP; Unph
Species Homo sapiens
Ensembl Gene ENSG00000114316
Encoded Proteins
IDBP-34597
ubiquitin specific peptidase 4 (proto-oncogene)
IDBP-34599
ubiquitin specific peptidase 4 (proto-oncogene)
IDBP-377176
ubiquitin specific peptidase 4 (proto-oncogene)
IDBP-377178
ubiquitin specific peptidase 4 (proto-oncogene)
IDBP-377179
ubiquitin specific peptidase 4 (proto-oncogene)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22262844
USP4 is a potent negative regulator of TLR/IL1Rsignalling through deubiquitination of TRAF6 to prevent activation of inflammatory responses.
InnateDB Annotation from Orthologs
Summary
PMID 22262844
[Mus musculus] Usp4 is a potent negative regulator of Tlr/Il1r-signalling through deubiquitination of Traf6 to prevent the activation of inflammatory responses.
Entrez Gene
Summary The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49277831-49340712
Strand Reverse strand
Band p21.31
Transcripts
ENST00000265560 ENSP00000265560
ENST00000351842 ENSP00000341028
ENST00000431357 ENSP00000399079
ENST00000416417 ENSP00000400623
ENST00000415188 ENSP00000408274
ENST00000483212
ENST00000485450
ENST00000475873
ENST00000486549
ENST00000488520
ENST00000461553
ENST00000462673
ENST00000464168
ENST00000491791
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 102 [view]
Protein-Protein 99 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0031685 adenosine receptor binding
GO:0036459 ubiquitinyl hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
GO:0031397 negative regulation of protein ubiquitination
GO:0031647 regulation of protein stability
GO:0034394 protein localization to cell surface
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032612
View Gene Order
ENSBTAG00000011899
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.738896 Hs.77500
RefSeq NM_001251877 NM_003363 NM_199443 XM_006710147 XM_006713452 XM_006726405
HUGO
OMIM
CCDS CCDS2793 CCDS2794 CCDS58832
HPRD 04598
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca