InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAPK7

Summary

InnateDB Protein

IDBP-34642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK7

Protein Name

mitogen-activated protein kinase 7

Synonyms

BMK1; ERK4; ERK5; PRKM7;

Species

Homo sapiens

Ensembl Protein

ENSP00000311005

InnateDB Gene

IDBG-34638 (MAPK7)

Protein Structure

UniProt Annotation

Function

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000269PubMed:11254654, ECO:0000269PubMed:11278431, ECO:0000269PubMed:22869143, ECO:0000269PubMed:9384584, ECO:0000269PubMed:9790194}.

Subcellular Localization

Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.

Disease Associations

Tissue Specificity

Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. {ECO:0000269PubMed:7759517}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.

Experimentally validated
Total	75 [view]
Protein-Protein	71 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004707	MAP kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0018105	peptidyl-serine phosphorylation
GO:0019933	cAMP-mediated signaling
GO:0030154	cell differentiation
GO:0030821	negative regulation of cAMP catabolic process
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response
GO:0045765	regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050728	negative regulation of inflammatory response
GO:0051247	positive regulation of protein metabolic process
GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051403	stress-activated MAPK cascade
GO:0051534	negative regulation of NFAT protein import into nucleus
GO:0060761	negative regulation of response to cytokine stimulus
GO:0070301	cellular response to hydrogen peroxide
GO:0071363	cellular response to growth factor stimulus
GO:0071499	cellular response to laminar fluid shear stress
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000352	negative regulation of endothelial cell apoptotic process
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016605	PML body

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt