InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GOT2

Summary

InnateDB Protein

IDBP-34709.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GOT2

Protein Name

glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)

Synonyms

KAT4; KATIV; mitAAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000245206

InnateDB Gene

IDBG-34707 (GOT2)

Protein Structure

UniProt Annotation

Function

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269PubMed:9537447}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:9537447}. Cell membrane {ECO:0000269PubMed:9537447}. Note=Exposure to alcohol promotes translocation to the cell membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity
GO:0016212	kynurenine-oxoglutarate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0044822	poly(A) RNA binding
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006103	2-oxoglutarate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006531	aspartate metabolic process
GO:0006532	aspartate biosynthetic process
GO:0006533	aspartate catabolic process
GO:0006536	glutamate metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0009058	biosynthetic process
GO:0015908	fatty acid transport
GO:0019470	4-hydroxyproline catabolic process
GO:0019550	glutamate catabolic process to aspartate
GO:0019551	glutamate catabolic process to 2-oxoglutarate
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0097052	L-kynurenine metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome