InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GOT2

Summary

InnateDB Gene

IDBG-34707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GOT2

Gene Name

glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)

Synonyms

KAT4; KATIV; mitAAT

Species

Homo sapiens

Ensembl Gene

ENSG00000125166

Encoded Proteins

IDBP-34709

glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)

IDBP-378368

glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)

IDBP-751850

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:58707131-58734357

Strand

Reverse strand

Band

q21

Transcripts

ENST00000245206	ENSP00000245206
ENST00000434819	ENSP00000394100
ENST00000494627
ENST00000496461
ENST00000492378
ENST00000564400
ENST00000568368	ENSP00000456205

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity
GO:0016212	kynurenine-oxoglutarate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0044822	poly(A) RNA binding
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006103	2-oxoglutarate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006531	aspartate metabolic process
GO:0006532	aspartate biosynthetic process
GO:0006533	aspartate catabolic process
GO:0006536	glutamate metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0009058	biosynthetic process
GO:0015908	fatty acid transport
GO:0019470	4-hydroxyproline catabolic process
GO:0019550	glutamate catabolic process to aspartate
GO:0019551	glutamate catabolic process to 2-oxoglutarate
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0097052	L-kynurenine metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome