InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGLYRP2

Summary

InnateDB Protein

IDBP-34756.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGLYRP2

Protein Name

peptidoglycan recognition protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000292609

InnateDB Gene

IDBG-34754 (PGLYRP2)

Protein Structure

UniProt Annotation

Function

May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity. {ECO:0000269PubMed:14506276}.

Subcellular Localization

Secreted. Membrane.

Disease Associations

Tissue Specificity

Strongly expressed in liver and fetal liver, and secreted into serum. Expressed to a much lesser extent in transverse colon, lymph nodes, heart, thymus, pancreas, descending colon, stomach and testis. Isoform 2 is not detected in the liver or serum. {ECO:0000269PubMed:11461926, ECO:0000269PubMed:16054449}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
GO:0016019	peptidoglycan receptor activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0001519	peptide amidation
GO:0002221	pattern recognition receptor signaling pathway
GO:0009253	peptidoglycan catabolic process
GO:0016045	detection of bacterium
GO:0045087	innate immune response (InnateDB)
GO:0050830	defense response to Gram-positive bacterium