InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PGLYRP2

Summary

InnateDB Gene

IDBG-34754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGLYRP2

Gene Name

peptidoglycan recognition protein 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000161031

Encoded Proteins

IDBP-34756

peptidoglycan recognition protein 2

IDBP-34758

peptidoglycan recognition protein 2

IDBP-764001

IDBP-760678

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20418257

PGLYRP2 is a secreted innate immunity protein that is expressed in the liver and is conserved from insects to mammals, it recognizes bacterial peptidoglycan, and functions in antibacterial immunity and inflammation.

PMID 21439073

PGLYRP2 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.

InnateDB Annotation from Orthologs

Summary

PMID 21439073

[Mus musculus] Pglyrp2 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.

Entrez Gene

Summary

This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:15468645-15498956

Strand

Reverse strand

Band

p13.12

Transcripts

ENST00000292609	ENSP00000292609
ENST00000340880	ENSP00000345968
ENST00000594637	ENSP00000470112
ENST00000601792	ENSP00000472856

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
GO:0016019	peptidoglycan receptor activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0001519	peptide amidation
GO:0002221	pattern recognition receptor signaling pathway
GO:0009253	peptidoglycan catabolic process
GO:0016045	detection of bacterium
GO:0032689	negative regulation of interferon-gamma production
GO:0032827	negative regulation of natural killer cell differentiation involved in immune response
GO:0044117	growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005622	intracellular
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000079563

View Gene Order

ENSBTAG00000012280

Not yet available

Cross-References

SwissProt

Q96PD5

TrEMBL

M0QYW3 M0R2W8

UniProt Splice Variant

Entrez Gene

114770

UniGene

Hs.282244

RefSeq

NM_052890 XM_006722633

HUGO

HGNC:30013

OMIM

608199

CCDS

CCDS12330

HPRD

IMGT

EMBL

AB073610 AC011492 AF384856 AK055882 AK289415 AK292292 AY358156 BC136551 BC136552 BC144238 CH471106

GenPept

AAI36552 AAI36553 AAI44239 AAL05629 AAQ88523 BAB71034 BAD38647 BAF82104 BAF84981 EAW84482 EAW84483

RNA Seq Atlas

114770