Version 5.4
Homo sapiens Protein: KRT72
Summary
InnateDB Protein IDBP-34805.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT72
Protein Name keratin 72
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000293745
InnateDB Gene IDBG-34803 (KRT72)
Protein Structure
UniProt Annotation
Function Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}.
Subcellular Localization
Disease Associations
Tissue Specificity Highly expressed in hair follicles from scalp and eyebrow. Also expressed in palmoplantar epidermis. Not expressed in face skin despite the presence of fine hairs histologically. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, its presence is delayed up to the height of the apex of the dermal papilla (at protein level). {ECO:0000269PubMed:11703281, ECO:0000269PubMed:12648212, ECO:0000269PubMed:16874310}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005198 structural molecule activity
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005882 intermediate filament
GO:0045095 keratin filament
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR003054 Keratin, type II
IPR009053 Prefoldin
PFAM PF00038
PRINTS PR01276
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14CN4
PhosphoSite PhosphoSite-Q14CN4
TrEMBL B4DXK4
UniProt Splice Variant
Entrez Gene 140807
UniGene Hs.662013
RefSeq NP_542785
HUGO HGNC:28932
OMIM 608246
CCDS CCDS8833
HPRD 09746
IMGT
EMBL AC055715 AK093060 AK293645 AK302016 AY033495 AY033496 BC113686
GenPept AAI13687 AAK55108 AAK55109 BAC04039 BAG57099 BAG63416

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca