InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDH5

Summary

InnateDB Protein

IDBP-34873.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH5

Protein Name

cadherin 5, type 2 (vascular endothelium)

Synonyms

7B4; CD144;

Species

Homo sapiens

Ensembl Protein

ENSP00000344115

InnateDB Gene

IDBG-34871 (CDH5)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. {ECO:0000269PubMed:20332120, ECO:0000269PubMed:21269602}.

Subcellular Localization

Cell junction {ECO:0000269PubMed:20332120}. Cell membrane {ECO:0000305PubMed:20332120}; Single-pass type I membrane protein {ECO:0000305PubMed:20332120}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.

Disease Associations

Tissue Specificity

Endothelial tissues and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0019903	protein phosphatase binding
GO:0044325	ion channel binding

Biological Process

GO:0001955	blood vessel maturation
GO:0007156	homophilic cell adhesion
GO:0008285	negative regulation of cell proliferation
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0045216	cell-cell junction organization
GO:2000114	regulation of establishment of cell polarity

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0071944	cell periphery